Background: Real-time, objective measures of adherence to antiretroviral therapy (ART) and pre-exposure prophylaxis\n(PrEP) are needed to better assess adherence levels and to expedite clinical response for those with suboptimal\nadherence. Point-of-care tenofovir (POC-TFV) testing has been proposed as a solution to facilitate real-time antiretroviral\nadherence monitoring, but little is known about how health care providers, people living with HIV (PLWH) receiving\nART, and people receiving PrEP will perceive POC-TFV testing.\nMethods: We conducted an exploratory qualitative study to assess perspectives on the utility and interest in POCTFV\ntesting from potential end users. We conducted three focus group discussions (FGDs) among 17 PLWH receiving\nART and four individuals receiving PrEP, as well as eight in-depth interviews (IDIs) with health care providers in\nthe Seattle area and presented participants with a hypothetical urine-based POC-TFV test. FGDs and IDIs were audio\nrecorded, transcribed, coded, and analyzed to describe emerging themes.\nResults: Overall, study participants demonstrated divergent opinions about the POC-TFV test. Among study participants,\nPLWH were most ambivalent about POC-TFV testing, first demonstrating reluctance to TFV-level monitoring\nand shifting positions during the FGDs. However, all PLWH participants were receptive...................
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